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Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy
Overexpression of ErbB-2/HER2 is associated with aggressive human malignancies, and therapeutic strategies targeting the oncoprotein are currently in different stages of clinical application. Tyrosine kinase inhibitors (TKIs) that block the nucleotide-binding site of the kinase are especially effect...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126014/ https://ncbi.nlm.nih.gov/pubmed/12006493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.10.2407 |
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