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Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

Overexpression of ErbB-2/HER2 is associated with aggressive human malignancies, and therapeutic strategies targeting the oncoprotein are currently in different stages of clinical application. Tyrosine kinase inhibitors (TKIs) that block the nucleotide-binding site of the kinase are especially effect...

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Udgivet i:EMBO J
Principais autores: Citri, Ami, Alroy, Iris, Lavi, Sara, Rubin, Chanan, Xu, Wanping, Grammatikakis, Nicolas, Patterson, Cam, Neckers, Len, Fry, David W., Yarden, Yosef
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126014/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12006493/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.10.2407
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