Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry
The misuse of antibiotics has selected for bacteria that have evolved mechanisms for evading the effects of these drugs. For aminoglycosides, a group of clinically important bactericidal antibiotics that target the A-site of the 16S ribosomal RNA, the most common mode of resistance is enzyme-catalyz...
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| Veröffentlicht in: | EMBO J |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126009/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12006485/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.10.2323 |
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