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JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells

Defining signals that can support the self-renewal of multipotential hemopoietic progenitor cells (MHPCs) is pertinent to understanding leukemogenesis and may be relevant to developing stem cell-based therapies. Here we define a set of signals, JAK2 plus either c-kit or flt-3, which together can sup...

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Udgivet i:EMBO J
Principais autores: Zhao, Shengming, Zoller, Karen, Masuko, Masayoshi, Rojnuckarin, Ponlapat, Yang, Xuexian O., Parganas, Evan, Kaushansky, Kenneth, Ihle, James N., Papayannopoulou, Thalia, Willerford, Dennis M., Clackson, Tim, Blau, C.Anthony
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125991/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11980713/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.9.2159
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