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A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines
In mammals, the four native deoxyribonucleosides are phosphorylated to the corresponding monophosphates by four deoxyribonucleoside kinases, which have specialized substrate specificities. These four enzymes are likely to originate from a common progenitor kinase. Insects appear to have only one mul...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125940/ https://ncbi.nlm.nih.gov/pubmed/11927571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.7.1873 |
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