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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53(–/–) cells
Aberrations in centrosome numbers have long been implicated in aneuploidy and tumorigenesis, but their origins are unknown. Here we have examined how overexpression of Aurora-A kinase causes centrosome amplification in cultured cells. We show that excess Aurora-A does not deregulate centrosome dupli...
Tallennettuna:
| Päätekijät: | , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2002
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125866/ https://ncbi.nlm.nih.gov/pubmed/11847097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.4.483 |
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