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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53(–/–) cells

Aberrations in centrosome numbers have long been implicated in aneuploidy and tumorigenesis, but their origins are unknown. Here we have examined how overexpression of Aurora-A kinase causes centrosome amplification in cultured cells. We show that excess Aurora-A does not deregulate centrosome dupli...

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Hlavní autoři: Meraldi, Patrick, Honda, Reiko, Nigg, Erich A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC125866/
https://ncbi.nlm.nih.gov/pubmed/11847097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.4.483
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