The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex

C1r is the modular serine protease (SP) that mediates autolytic activation of C1, the macromolecular complex that triggers the classical pathway of complement. The crystal structure of a mutated, proenzyme form of the catalytic domain of human C1r, comprising the first and second complement control...

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Publicat a:	EMBO J
Autors principals:	Budayova-Spano, Monika, Lacroix, Monique, Thielens, Nicole M., Arlaud, Gérard J., Fontecilla-Camps, Juan Carlos, Gaboriaud, Christine
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2002
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125823/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11823416/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.3.231
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