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Improvement in protein functional site prediction by distinguishing structural and functional constraints on protein family evolution using computational design
The prediction of functional sites in newly solved protein structures is a challenge for computational structural biology. Most methods for approaching this problem use evolutionary conservation as the primary indicator of the location of functional sites. However, sequence conservation reflects not...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1258172/ https://ncbi.nlm.nih.gov/pubmed/16224101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki894 |
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