Dysregulation of TGF-β1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice

The core fucosylation (α1,6-fucosylation) of glycoproteins is widely distributed in mammalian tissues, and is altered under pathological conditions. To investigate physiological functions of the core fucose, we generated α1,6-fucosyltransferase (Fut8)-null mice and found that disruption of Fut8 indu...

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Main Authors: Wang, Xiangchun, Inoue, Shinya, Gu, Jianguo, Miyoshi, Eiji, Noda, Katsuhisa, Li, Wenzhe, Mizuno-Horikawa, Yoko, Nakano, Miyako, Asahi, Michio, Takahashi, Motoko, Uozumi, Naofumi, Ihara, Shinji, Lee, Seung Ho, Ikeda, Yoshitaka, Yamaguchi, Yukihiro, Aze, Yoshiya, Tomiyama, Yoshiaki, Fujii, Junichi, Suzuki, Keiichiro, Kondo, Akihiro, Shapiro, Steven D., Lopez-Otin, Carlos, Kuwaki, Tomoyuki, Okabe, Masaru, Honke, Koichi, Taniguchi, Naoyuki
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257418/
https://ncbi.nlm.nih.gov/pubmed/16236725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507375102
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