Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53

Using highly purified proteins, we have identified intermediate reactions that lead to the assembly of molecular chaperone complexes with wild-type or mutant p53R175H protein. Hsp90 possesses higher affinity for wild-type p53 than for the conformational mutant p53R175H. The presence of Hsp90 in a co...

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Pubblicato in:	EMBO J
Autori principali:	King, Frank W., Wawrzynow, Alicja, Höhfeld, Jörg, Zylicz, Maciej
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125724/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6297
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