Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase
Human MutLα, a heterodimer of hMLH1 and hPMS2, is essential for DNA mismatch repair. Inactivation of the hmlh1 or hpms2 genes by mutation or epigenesis causes genomic instability and a predisposition to hereditary non-polyposis cancer. We report here the X-ray crystal structures of the conserved N-t...
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| Udgivet i: | EMBO J |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125661/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11574484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.19.5521 |
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