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The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

PKR, a member of the eukaryotic initiation-factor 2α (eIF-2α) kinase family, mediates the host antiviral response and is implicated in tumor suppression and apoptosis. Here we show that PKR is regulated by the heat shock protein 90 (Hsp90) molecular chaperone complex. Mammalian PKR expressed in budd...

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Udgivet i:EMBO J
Principais autores: Donzé, Olivier, Abbas-Terki, Toufik, Picard, Didier
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125551/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447118/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.14.3771
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