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Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion
Feedback is a ubiquitous control mechanism of gene networks. Here, we have used positive feedback to construct a synthetic eukaryotic gene switch in Saccharomyces cerevisiae. Within this system, a continuous gradient of constitutively expressed transcriptional activator is translated into a cell phe...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125456/ https://ncbi.nlm.nih.gov/pubmed/11350942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.10.2528 |
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