TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

Transforming growth factor-β (TGF-β), a secreted factor present at high levels in bone, inhibits osteoblast differentiation in culture; yet, the mechanism of this inhibition remains unclear. We studied the effects of TGF-β and its effectors, the Smads, on the expression and function of the osteoblas...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Alliston, Tamara, Choy, Lisa, Ducy, Patricia, Karsenty, Gérard, Derynck, Rik
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11331591/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.9.2254
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