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Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin
To investigate the role of retinoid X receptors (RXRs) in epidermal homeostasis, we generated RXRαβ(ep-/-) somatic mutants in which both RXRα and RXRβ are selectively ablated in epidermal keratinocytes of adult mice. These mice develop a chronic dermatitis mimicking that observed in atopic dermatiti...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1253602/ https://ncbi.nlm.nih.gov/pubmed/16199515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507385102 |
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