Structure-based analysis of RNA polymerase function: the largest subunit’s rudder contributes critically to elongation complex stability and is not involved in the maintenance of RNA–DNA hybrid length

Analysis of multisubunit RNA polymerase (RNAP) structures revealed several elements that may constitute the enzyme’s functional sites. One such element, the ‘rudder’, is formed by an evolutionarily conserved segment of the largest subunit of RNAP and contacts the nascent RNA at the upstream edge of...

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Autores principales: Kuznedelov, Konstantin, Korzheva, Nataliya, Mustaev, Arkady, Severinov, Konstantin
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC125355/
https://ncbi.nlm.nih.gov/pubmed/11889042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.6.1369
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