Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27(Kip1) and p18(INK4c)

Menin, the product of the Men1 gene mutated in familial multiple endocrine neoplasia type 1 (MEN1), regulates transcription in differentiated cells. Menin associates with and modulates the histone methyltransferase activity of a nuclear protein complex to activate gene expression. However, menin-dep...

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Bibliographic Details
Main Authors: Karnik, Satyajit K., Hughes, Christina M., Gu, Xueying, Rozenblatt-Rosen, Orit, McLean, Graeme W., Xiong, Yue, Meyerson, Matthew, Kim, Seung K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253549/
https://ncbi.nlm.nih.gov/pubmed/16195383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503484102
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