Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice

Anti-tumor-necrosis-factor-α (TNF-α) monoclonal antibody was used to treat Tg197 transgenic mice, which constitutively produce human TNF-α (hTNF-α) and develop a progressive polyarthritic disease. Treatment of both young (7- or 8-week-old) and aged (27- or 28-week-old) mice commenced when at least t...

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Autores principales: Shealy, David J, Wooley, Paul H, Emmell, Eva, Volk, Amy, Rosenberg, Amy, Treacy, George, Wagner, Carrie L, Mayton, Lois, Griswold, Don E, Song, Xiao-yu R
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC125301/
https://ncbi.nlm.nih.gov/pubmed/12223110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar430
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