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parC Mutations in Fluoroquinolone-Resistant Borrelia burgdorferi
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the fi...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1251557/ https://ncbi.nlm.nih.gov/pubmed/16189120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.10.4354-4357.2005 |
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