Limited Polymorphism in the Dihydropteroate Synthetase Gene (dhps) of Plasmodium vivax Isolates from Thailand

The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrime...

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Autors principals: Imwong, Mallika, Pukrittayakamee, Sasithon, Cheng, Qin, Moore, Catrin, Looareesuwan, Sornchai, Snounou, Georges, White, Nicholas J., Day, Nicholas P. J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1251524/
https://ncbi.nlm.nih.gov/pubmed/16189131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.10.4393-4395.2005
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