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Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3

The neuroendocrine processing endoproteases PC2 and PC1/3 are expressed in the β cells of the islets of Langerhans and participate in the processing of proinsulin to insulin and C-peptide. We have previously shown that disruption of PC2 (SPC2) expression significantly impairs proinsulin processing....

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zhu, Xiaorong, Orci, Lelio, Carroll, Raymond, Norrbom, Christina, Ravazzola, Mariella, Steiner, Donald F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124908/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12136131/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162352799
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