An Intertypic Herpes Simplex Virus Helicase-Primase Complex Associated with a Defect in Neurovirulence Has Reduced Primase Activity

R13-1 is an intertypic recombinant virus in which the left-hand 18% of the herpes simplex virus type 1 (HSV-1) genome is replaced by homologous sequences from HSV-2. R13-1 is nonneurovirulent and defective in DNA replication in neurons. The defect was localized to the UL5 open reading frame by using...

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Pubblicato in:	J Virol
Autori principali:	Barrera, I., Bloom, D., Challberg, M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124597/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9445019/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.2.1203-1209.1998
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