Structure-based design of mutant Methanococcus jannaschii tyrosyl-tRNA synthetase for incorporation of O-methyl-l-tyrosine

Although incorporation of amino acid analogs provides a powerful means of producing new protein structures with interesting functions, many amino acid analogs cannot be incorporated easily by using the wild-type aminoacyl-tRNA synthetase (aaRS). To be able to incorporate specific amino acid analogs...

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Detalles Bibliográficos
Main Authors: Zhang, Deqiang, Vaidehi, Nagarajan, Goddard, William A., Danzer, Joseph F., Debe, Derek
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC124445/
https://ncbi.nlm.nih.gov/pubmed/12011422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052150499
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