Using deeply trapped intermediates to map the cytochrome c folding landscape

Replacement of iron with cobalt(III) selectively introduces a deep trap in the folding-energy landscape of the heme protein cytochrome c. Remarkably, neither the protein structure nor the folding thermodynamics is perturbed by this metal–ion substitution, as shown by data from spectroscopic and x-ra...

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Bibliographic Details
Main Authors: Tezcan, F. Akif, Findley, William M., Crane, Brian R., Ross, Scott A., Lyubovitsky, Julia G., Gray, Harry B., Winkler, Jay R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC124336/
https://ncbi.nlm.nih.gov/pubmed/12084923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132254499
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