Specific zinc-finger architecture required for HIV-1 nucleocapsid protein's nucleic acid chaperone function

The nucleocapsid protein (NC) of HIV type 1 (HIV-1) is a nucleic acid chaperone that facilitates the rearrangement of nucleic acid secondary structure during reverse transcription. HIV-1 NC contains two CCHC-type zinc binding domains. Here, we use optical tweezers to stretch single λ-DNA molecules t...

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Bibliographic Details
Main Authors: Williams, Mark C., Gorelick, Robert J., Musier-Forsyth, Karin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC124332/
https://ncbi.nlm.nih.gov/pubmed/12084921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132128999
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