Proximity-induced activation of human Cdc34 through heterologous dimerization

Cdc34 is an E2-conjugating enzyme required for catalyzing the polyubiquitination reaction mediated by the Skp1·CUL1·F-box (SCF) protein E3 ubiquitin (Ub) ligase. Here, we show that the activity of human Cdc34 in the Ub–Ub ligation reaction was enhanced dramatically by SCF's core Ub ligase modul...

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Autori principali: Gazdoiu, Stefan, Yamoah, Kosj, Wu, Kenneth, Escalante, Carlos R., Tappin, Inger, Bermudez, Vladimir, Aggarwal, Aneel K., Hurwitz, Jerard, Pan, Zhen-Qiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242854/
https://ncbi.nlm.nih.gov/pubmed/16210246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507646102
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