From flies' eyes to our ears: Mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30

Normal vision in Drosophila requires NINAC, a class III myosin. Class III myosins are hybrid motor-signaling molecules, with an N-terminal kinase domain, highly conserved head and neck domains, and a class III-specific tail domain. In Drosophila rhabdomeres, NINAC interacts with actin filaments and...

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Bibliographic Details
Main Authors: Walsh, Tom, Walsh, Vanessa, Vreugde, Sarah, Hertzano, Ronna, Shahin, Hashem, Haika, Smadar, Lee, Ming K., Kanaan, Moien, King, Mary-Claire, Avraham, Karen B.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC124268/
https://ncbi.nlm.nih.gov/pubmed/12032315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.102091699
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