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Amyloid aggregates of the HET-s prion protein are infectious

The [Het-s] infectious element of the filamentous fungus Podospora anserina is a prion. We have recently reported that recombinant HET-s protein aggregates in vitro into amyloid fibers. In vivo, the protein aggregates specifically in the [Het-s] prion strains. Here, we show that biolistic introducti...

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Autores principales: Maddelein, Marie-Lise, Dos Reis, Suzana, Duvezin-Caubet, Stéphane, Coulary-Salin, Bénédicte, Saupe, Sven J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC124243/
https://ncbi.nlm.nih.gov/pubmed/12032295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072199199
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