Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages

IFN regulatory factor (IRF) 8 is a transcription factor that directs macrophage differentiation. By fluorescence recovery after photobleaching, we visualized the movement of IRF8-GFP in differentiating macrophages. Recovery data fitted to mathematical models revealed two binding states for IRF8. The...

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Bibliographic Details
Main Authors: Laricchia-Robbio, Leopoldo, Tamura, Tomohiko, Karpova, Tatiana, Sprague, Brian L., McNally, James G., Ozato, Keiko
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242294/
https://ncbi.nlm.nih.gov/pubmed/16183743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504014102
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