Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a Vaccinia virus recombinant

BACKGROUND: Hepatitis C virus (HCV) infection is of growing concern in public health with around 350 million chronically infected individuals worldwide. Although the IFN-α/rivabirin is the only approved therapy with 10–30% clinical efficacy, the protective molecular mechanism involved during the tre...

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Detalhes bibliográficos
Main Authors: Gómez, Carmen E, Vandermeeren, Andrée Marie, García, María Angel, Domingo-Gil, Elena, Esteban, Mariano
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242258/
https://ncbi.nlm.nih.gov/pubmed/16156900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-2-81
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