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Adaptive designs based on the truncated product method

BACKGROUND: Adaptive designs are becoming increasingly important in clinical research. One approach subdivides the study into several (two or more) stages and combines the p-values of the different stages using Fisher's combination test. METHODS: Alternatively to Fisher's test, the recentl...

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Detalhes bibliográficos
Main Authors: Neuhäuser, Markus, Bretz, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242234/
https://ncbi.nlm.nih.gov/pubmed/16171518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-5-30
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