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Natural variability and the influence of concurrent control values on the detection and interpretation of low-dose or weak endocrine toxicities.

While defining the no effect level for the 5 alpha-reductase inhibitor finasteride in the Hershberger assay, we encountered an inverted-U low-dose trophic effect on the prostate gland of the rat. Two attempts to confirm this observation were unsuccessful, and we concluded that the positive effect in...

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Autors principals: Ashby, John, Tinwell, Helen, Odum, Jenny, Lefevre, Paul
Format: Artigo
Idioma:Inglês
Publicat: 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242011/
https://ncbi.nlm.nih.gov/pubmed/15175171
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