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AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model.

The promotion-sensitive mouse epidermal JB6 cells (clone 41) have been used to identify the tumor-promoting activity of various compounds. Because treatment by tumor promoters [12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), or tumor necrosis factor alpha (TNF-alpha)] tran...

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Hlavní autoři: Suzukawa, Kazumi, Weber, Thomas J, Colburn, Nancy H
Médium: Artigo
Jazyk:Inglês
Vydáno: 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1240984/
https://ncbi.nlm.nih.gov/pubmed/12204819
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