Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening illness caused by deficiency of the vWF-cleaving protease ADAMTS13. Here we show that ADAMTS13-deficient mice are viable and exhibit normal survival, although vWF-mediated platelet-endothelial interactions are significantly prolonged. I...

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Detalhes bibliográficos
Main Authors: Motto, David G., Chauhan, Anil K., Zhu, Guojing, Homeister, Jonathon, Lamb, Colin B., Desch, Karl C., Zhang, Weirui, Tsai, Han-Mou, Wagner, Denisa D., Ginsburg, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1240119/
https://ncbi.nlm.nih.gov/pubmed/16200209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26007
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