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Cyclophilin A is required for TRIM5α-mediated resistance to HIV-1 in Old World monkey cells

The peptidyl-prolyl isomerase cyclophilin A (CypA) embraces an exposed, proline-rich loop on HIV-1 capsid (CA) and renders reverse transcription complexes resistant to an antiviral activity in human cells. A CypA fusion with TRIM5 that is unique to New World owl monkeys also targets HIV-1 CA, but th...

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Bibliografske podrobnosti
Main Authors: Berthoux, Lionel, Sebastian, Sarah, Sokolskaja, Elena, Luban, Jeremy
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1239943/
https://ncbi.nlm.nih.gov/pubmed/16203999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505659102
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