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Cyclophilin A is required for TRIM5α-mediated resistance to HIV-1 in Old World monkey cells
The peptidyl-prolyl isomerase cyclophilin A (CypA) embraces an exposed, proline-rich loop on HIV-1 capsid (CA) and renders reverse transcription complexes resistant to an antiviral activity in human cells. A CypA fusion with TRIM5 that is unique to New World owl monkeys also targets HIV-1 CA, but th...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1239943/ https://ncbi.nlm.nih.gov/pubmed/16203999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505659102 |
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