Graded Inhibition of Pulsatile Luteinizing Hormone Secretion by a Selective Gonadotropin-Releasing Hormone (GnRH)-Receptor Antagonist in Healthy Men: Evidence That Age Attenuates Hypothalamic GnRH Outflow

Healthy older men manifest concomitant hypoandrogenemia and attenuation of LH pulse size. Because exogenous GnRH remains effective, a plausible intuition is that aging reduces hypothalamic GnRH secretion, thus mediating relative hypogonadotropic hypogonadism. To assess the impact of age on central G...

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Главные авторы: Takahashi, Paul Y., Liu, Peter Y., Roebuck, Pamela D., Iranmanesh, Ali, Veldhuis, Johannes D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2005
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1236990/
https://ncbi.nlm.nih.gov/pubmed/15741251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2004-2521
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