Role of poly(ADP-ribosyl)ation in DNA-PK(cs)- independent V(D)J recombination

V(D)J recombination is critical to the generation of a functional immune system. Intrinsic to the assembly of antigen receptor genes is the formation of endogenous DNA double-strand breaks, which normally are excluded from the cellular surveillance machinery because of their sequestration in a synap...

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Bibliographic Details
Main Authors: Brown, Matthew L., Franco, Daniel, Bürkle, Alexander, Chang, Yung
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC123682/
https://ncbi.nlm.nih.gov/pubmed/11930007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072495299
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