Deficits in amygdaloid cAMP-responsive element–binding protein signaling play a role in genetic predisposition to anxiety and alcoholism

We investigated the role of cAMP-responsive element–binding protein (CREB) in genetic predisposition to anxiety and alcohol-drinking behaviors using alcohol-preferring (P) and -nonpreferring (NP) rats. The levels of CREB, phosphorylated CREB, and neuropeptide Y (NPY) were innately lower in the centr...

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Detalhes bibliográficos
Main Authors: Pandey, Subhash C., Zhang, Huaibo, Roy, Adip, Xu, Tiejun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1236671/
https://ncbi.nlm.nih.gov/pubmed/16200210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24381
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