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Depletion of Saccharomyces cerevisiae tRNA(His) Guanylyltransferase Thg1p Leads to Uncharged tRNA(His) with Additional m(5)C

The essential Saccharomyces cerevisiae tRNA(His) guanylyltransferase (Thg1p) is responsible for the unusual G(−1) addition to the 5′ end of cytoplasmic tRNA(His). We report here that tRNA(His) from Thg1p-depleted cells is uncharged, although histidyl tRNA synthetase is active and the 3′ end of the t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gu, Weifeng, Hurto, Rebecca L., Hopper, Anita K., Grayhack, Elizabeth J., Phizicky, Eric M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234336/
https://ncbi.nlm.nih.gov/pubmed/16135808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.18.8191-8201.2005
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