Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27(Kip1) Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling

Overactivation of Ras pathways contributes to oncogenesis and metastasis of epithelial cells in several ways, including interference with cell cycle regulation via the CDK inhibitor p27(Kip1) (p27) and disruption of transforming growth factor β (TGF-β) anti-proliferative activity. Here, we show that...

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Detalhes bibliográficos
Main Authors: Kfir, Shiri, Ehrlich, Marcelo, Goldshmid, Ayelet, Liu, Xuedong, Kloog, Yoel, Henis, Yoav I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234306/
https://ncbi.nlm.nih.gov/pubmed/16135812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.18.8239-8250.2005
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