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Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution.

The degradation products of recombinant human interleukin-1 receptor antagonist (rhIL-1ra) formed during storage at 30 degrees C in aqueous solution were characterized. Cationic exchange chromatography of the stored sample showed two major, new peaks eluting before (P1) and after (L2) the native pro...

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Detalhes bibliográficos
Main Authors: Chang, B S, Beauvais, R M, Arakawa, T, Narhi, L O, Dong, A, Aparisio, D I, Carpenter, J F
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1233827/
https://ncbi.nlm.nih.gov/pubmed/8968609
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