IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions

Atopic dermatitis (AD) is a pruritic inflammatory skin disease. Because IL-18 directly stimulates T cells and mast cells to release AD-associated molecules, Th2 cytokines, and histamine, we investigated the capacity of IL-18 to induce AD-like inflammatory skin disease by analyzing KIL-18Tg and KCASP...

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Detalhes bibliográficos
Main Authors: Konishi, Hiroshi, Tsutsui, Hiroko, Murakami, Takaaki, Yumikura-Futatsugi, Shizue, Yamanaka, Kei-ichi, Tanaka, Minoru, Iwakura, Yohichiro, Suzuki, Noboru, Takeda, Kiyoshi, Akira, Shizuo, Nakanishi, Kenji, Mizutani, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123258/
https://ncbi.nlm.nih.gov/pubmed/12151598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152337799
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