Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo

Retroviral reverse transcriptases contain a DNA polymerase activity that can copy an RNA or DNA template and an RNase H activity that degrades the viral RNA genome during reverse transcription. RNase H makes both specific and nonspecific cleavages; specific cleavages are used to generate and remove...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Julias, John G., McWilliams, Mary Jane, Sarafianos, Stefan G., Arnold, Edward, Hughes, Stephen H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123172/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.142123199
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