Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo

Retroviral reverse transcriptases contain a DNA polymerase activity that can copy an RNA or DNA template and an RNase H activity that degrades the viral RNA genome during reverse transcription. RNase H makes both specific and nonspecific cleavages; specific cleavages are used to generate and remove...

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Detalles Bibliográficos
Main Authors: Julias, John G., McWilliams, Mary Jane, Sarafianos, Stefan G., Arnold, Edward, Hughes, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC123172/
https://ncbi.nlm.nih.gov/pubmed/12093908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.142123199
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