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Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
Erk5 is a mitogen-activated protein kinase, the biological role of which is largely undefined. Therefore, we deleted the erk5 gene in mice to assess its function in vivo. Inactivation of the erk5 gene resulted in defective blood-vessel and cardiac development leading to embryonic lethality around em...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC123126/ https://ncbi.nlm.nih.gov/pubmed/12093914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.142293999 |
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