Heteropentameric Cholera Toxin B Subunit Chimeric Molecules Genetically Fused to a Vaccine Antigen Induce Systemic and Mucosal Immune Responses: a Potential New Strategy To Target Recombinant Vaccine Antigens to Mucosal Immune Systems

Noninvasive mucosal vaccines are attractive alternatives to parenteral vaccines. Although the conjugation of vaccine antigens with the B subunit of cholera toxin (CTB) is one of the most promising strategies for vaccine delivery to mucosal immune systems, the molecule cannot tolerate large-protein f...

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Detalhes bibliográficos
Principais autores: Harakuni, Tetsuya, Sugawa, Hideki, Komesu, Ai, Tadano, Masayuki, Arakawa, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1231140/
https://ncbi.nlm.nih.gov/pubmed/16113283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.9.5654-5665.2005
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