Mannheimia haemolytica Leukotoxin Induces Apoptosis of Bovine Lymphoblastoid Cells (BL-3) via a Caspase-9-Dependent Mitochondrial Pathway

Mannheimia haemolytica is a key pathogen in the bovine respiratory disease complex. It produces a leukotoxin (LKT) that is an important virulence factor, causing cell death in bovine leukocytes. The LKT binds to the β(2) integrin CD11a/CD18, which usually activates signaling pathways that facilitate...

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Detalhes bibliográficos
Main Authors: Atapattu, Dhammika N., Czuprynski, Charles J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1231077/
https://ncbi.nlm.nih.gov/pubmed/16113266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.9.5504-5513.2005
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