Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors

Gene transfer vectors based on lentiviruses can transduce terminally differentiated cells in the brain; however, their ability to reverse established behavioral deficits in animal models of neurodegeneration has not previously been tested. When recombinant feline immunodeficiency virus (FIV)-based v...

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Detalhes bibliográficos
Main Authors: Brooks, Andrew I., Stein, Colleen S., Hughes, Stephanie M., Heth, Jason, McCray, Paul M., Sauter, Sybille L., Johnston, Julie C., Cory-Slechta, Deborah A., Federoff, Howard J., Davidson, Beverly L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122929/
https://ncbi.nlm.nih.gov/pubmed/11959904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.082011999
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