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Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography

Activation of G protein-coupled receptors (GPCRs) is triggered and regulated by structural rearrangement of the transmembrane heptahelical bundle containing a number of highly conserved residues. In rhodopsin, a prototypical GPCR, the helical bundle accommodates an intrinsic inverse-agonist 11-cis-r...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Okada, Tetsuji, Fujiyoshi, Yoshinori, Silow, Maria, Navarro, Javier, Landau, Ehud M., Shichida, Yoshinori
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences 2002
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC122888/
https://ncbi.nlm.nih.gov/pubmed/11972040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.082666399
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