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Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal

Cerebral ischemia stimulates increased activity of polyamine oxidase, a ubiquitous enzyme that catabolizes polyamines to produce 3-aminopropanal. 3-Aminopropanal is a reactive aldehyde that mediates progressive neuronal necrosis and glial apoptosis. Here we report that increased levels of 3-aminopro...

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Sparad:
I publikationen:Proc Natl Acad Sci U S A
Huvudupphov: Ivanova, Svetlana, Batliwalla, Franak, Mocco, J., Kiss, Szilard, Huang, Judy, Mack, William, Coon, Alexander, Eaton, John W., Al-Abed, Yousef, Gregersen, Peter K., Shohami, Esther, Connolly, E. Sander, Tracey, Kevin J.
Materialtyp: Artigo
Språk:Inglês
Utgiven: National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122812/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11943872/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.082609299
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