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Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity

Type III polyketide synthases (PKS) generate an array of natural products by condensing multiple acetyl units derived from malonyl-CoA to thioester-linked starter molecules covalently bound in the PKS active site. One strategy adopted by Nature for increasing the functional diversity of these biosyn...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Jez, Joseph M., Bowman, Marianne E., Noel, Joseph P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122767/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11959984/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.082590499
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